| Autoantibody | Associated Condition |
|---|---|
| ANA (antinuclear antibody) | SLE, MCTD, SSc, PM, DM, SjS, RA, aging |
| ACPA (anti-citrullinated protein antibody) or CCP (cyclic citrullinated peptides) | RA, PsA, TB |
| dsDNA | SLE |
| Sm (Smith) | SLE |
| Ro (SS-A) | SjS, SLE |
| La (SS-B) | SjS, SLE |
| Centromere | lcSSc (CREST syndrome), PBC |
| Scl-70 (topoisomerase I) | dcSSc |
| Jo-1 (histidyl-tRNA synthetase) | PM/DM |
| PL-7 (threonyl-tRNA synthetase) | PM/DM with ILD |
| PM/Scl (exosome complex) | PM-SSc overlap syndrome |
| C1q | Hypocomplementemic urticarial vasculitis |
| aCL (anti-cardiolipin antibody) | APS |
| β2GI (β2-glycoprotein I) | APS |
| LA (lupus anticoagulant) | APS |
| U1-RNP (snRNP70, U1 small nuclear ribonucleoprotein 70 kDa) | MCTD |
| RF (rheumatoid factor) | RA, SLE, SSc, MCTD, SjS, PM, cryoglobulinemia, HIV, TB, chronic infection, sarcoidosis, malignancy |
| Low C3, C4 | Cryoglobulinemia, MPGN, PSGN, SLE, RA, urticarial vasculitis, subacute bacterial endocarditis |
| Cryoglobulins | Cryoglobulinemia |
| c-ANCA (cytoplasmic anti-neutrophil cytoplasm antibody), PR3 ⊕ | Microscopic polyangiitis, Churg-Strauss syndrome, Wegener granulomatosis |
| p-ANCA (perinuclear anti-neutrophil cytoplasm antibody), MPO ⊕ | Microscopic polyangiitis, Churg-Strauss syndrome, Wegener granulomatosis |
| p-ANCA (perinuclear anti-neutrophil cytoplasm antibody), MPO ⊖ | UC, autoimmune hepatitis, RA, SLE, HIV, chronic infection, malignancy |
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Autoantibodies and associated conditions
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